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19 Mar 2018 How I quit Zoloft and Wellbutrin and used CBD for depression and anxiety During this time I continued taking Wellbutrin and using cannabis  As official studies on CBD and Wellbutrin itself are sparse, many users of such antidepressant medications are taking the conversation online regarding CBD's  The following provides more information about Wellbutrin in general and also highlights how marijuana and Wellbutrin could interact with one another. Wellbutrin is one of the more popular antidepressants today because it of three psychiatric medications including Wellbutrin, another antidepressant, and a mood "CBD and THC are also seen to be able to 'bind' or sit in and activate the